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Best Antidepressants: A Guide to Finding the Right One

Choosing the best antidepressant is not a simple process. Effective medications from the past are a good starting point. New users of antidepressants should consider the risks involved in making their selection.


It is not always easy to get the proper treatment for depression when you are already dealing with the emotional stress that depression creates. There are many varieties to choose from, and it is worth knowing how various kinds of medications work, the side effects they induce, and how to discover the particular type that suits you best.

This guide helps make the process easier and more personal.

Understanding Depression Medication

Antidepressants work to treat depression by controlling symptoms of mood disorders, anxiety, and other mental conditions. The fact is that these antidepressant drugs react by modifying the chemical balance in our brain, especially neurotransmitters such as serotonin, norepinephrine, and dopamine. These are mood, energy, and focus chemicals.

Every medication does not take effect in the same manner. What works well for one individual may not work for another. That is why the selection of certain types of antidepressants is determined by your healthcare provider.

Types of Depression Medication

There are some key types of treatments commonly prescribed for depression with various advantages and side effects. This antidepressants list enables you and your physician to make a better choice.

Selective Serotonin Reuptake Inhibitors (SSRIs)

Most frequently, SSRI is the first prescription to manage the symptoms of depression since it has fewer side effects compared to its predecessors. They occur by boosting the brain’s serotonin levels.

Common SSRIs include:

  1. Fluoxetine (Prozac)
  2. Sertraline (Zoloft)
  3. Citalopram (Celexa)
  4. Escitalopram (Lexapro)
  5. Paroxetine (Paxil)

Serotonin and Norepinephrine Reuptake Inhibitors (SNRIs)

SNRIs raise the norepinephrine and serotonin levels. They may be prescribed by doctors if SSRIs do not work. Together, the most popular treatment responses are SSRI and SNRI.

Examples include:

  1. Venlafaxine (Effexor XR)
  2. Duloxetine (Cymbalta)
  3. Desvenlafaxine (Pristiq)

These serotonin and norepinephrine reuptake medications are beneficial for those dealing with depression and anxiety.

Tricyclic Antidepressants

Tricyclic antidepressants belong to a more outdated form of depression treatment. Doctors do not often take medications of this type unless newer antidepressants have already failed since they are likely to produce more adverse reactions even though they are effective.

Examples include:

  1. Amitriptyline
  2. Nortriptyline (Pamelor)
  3. Imipramine (Tofranil)

Monoamine Oxidase Inhibitors (MAOIs)

The MAOIs are more potent, but they are less common due to food limitations and potential interactions. They can suggest them to be used in cases where the others fail.

Examples include:

  1. Phenelzine (Nardil)
  2. Tranylcypromine (Parnate)
  3. Isocarboxazid (Marplan)

Doctors reserve monoamine oxidase inhibitors for severe or treatment-resistant cases and closely monitor patients who take them.

Atypical Antidepressants

The atypical antidepressants are not part of any primary categories but they remain widely used in the fight against depressive symptoms.

Examples include:

  1. Bupropion (Wellbutrin) can increase energy or help you with smoking.
  2. Mirtazapine (Remeron) commonly assists with sleep and appetite.
  3. Trazodone, which is normally used in the treatment of depression, is also applied to treat insomnia.

How to Choose the Right Treatment

The necessary medication can only be found based on several individual factors:

  1. Your specific symptoms: Some drugs are more suitable for anxiety, while others are better for fatigue, concentration, or sleep.
  2. Side effects: You will react with some drugs better than with some.
  3. Existing medical conditions: Depending on the health history, specific alternatives can be safer than others.
  4. Current medications: Drug interactions should also be taken into consideration.
  5. Family history: If a family member responded well to a particular drug, it might work for you, too.

The majority of antidepressants need a few weeks to start working.

Possible Side Effects

Antidepressants may also come with side effects despite the efficiency of the medication. Such effects may be weak and short-lived, but it’s essential to check how you react.

Common side effects are:

  1. Nausea or stomach discomfort
  2. Headaches
  3. Insomnia or drowsiness
  4. Weight gain or loss
  5. Sexual difficulties
  6. Dry mouth or lightheadedness

Always report unusual or severe reactions to your provider. A simple dosage adjustment or medication switch may resolve the issue.

Do These Medications Work?

Yes. Antidepressant medications are FDA-approved and supported by decades of research. They help reduce depressive symptoms and balance mood, making therapy and self-care more effective.

Most people benefit from combining medication with talk therapy, physical activity, and social support. This combined approach tends to result in long-term recovery and emotional balance.

What If the First Option Fails?

Individuals tend to take the help of more than one drug before identifying the right one. Provided that the initial treatment is not sufficient to relief, your doctor can:

  1. Medicate the dose
  2. Change of drug
  3. Add a second medication
  4. Prescribe other kinds of treatment like therapy or lifestyle adjustments

Complementary Treatments

Besides medication, therapy and support play a role:

  1. Talk therapy (like CBT or DBT) helps you develop coping skills and learn healthy ways of dealing with depression.
  2. Lifestyle adjustments, such as regular exercise, sleep, and a balanced diet.
  3. Support groups: offer a place to connect with others facing similar challenges.
  1. Where can I access depression treatment in Spokane Valley?

    We Level Up Washington provides therapy, medication management, and holistic support for people facing depression and anxiety.

  2. What is the most suitable treatment for depressive symptoms?

    It depends on your symptoms, health history, and how your body responds to treatment. At We Level Up Washington, our team provides evaluations and customized medication plans tailored to your specific needs.

  3. Do people often take antidepressants safely over the long term?

    Yes. Many individuals use them long-term, under regular medical supervision, to ensure ongoing effectiveness and minimize side effects.

  4. How long does it usually take for antidepressants to start working?

    It generally takes 2 to 4 weeks to notice improvement, with full benefits developing over 6 to 8 weeks.

  5. Is it safe to stop taking antidepressants without guidance?

    No. Never stop without talking to your provider. Withdrawal symptoms or a depression relapse can be provoked by suddenly stopping.

Final Thoughts

Depression is a lonely and complex process to go through, but with a proper treatment regimen, you can stay hopeful, as it can ease the burden of depression. Regardless of whether you enter your first prescription or renew your treatment after a relapse, you should be patient or open communication with your medical service.

At We Level Up Washington, we will accompany you throughout each step of your recovery. The team of professionals at We Level Up Washington provides expert assistance in the fields of medication administration, therapy, and mental health services to help individuals gain control and find peace.

If one of your family members is in need, call now. Begin your path to recovery today.